|
KMID : 0387820120190020118
|
|
Clinical Pediatric Hematology-Oncology
2012 Volume.19 No. 2 p.118 ~ p.122
|
|
|
A Case of Oligodendroglioma after Treatment of Acute Lymphoblastic Leukemia in Childhood
|
|
Shin Sang-Hoon
Chung Bo-Hyun
Siegfried Bauer
Lee Jung-Hwa
Lee Kwang-Chul
|
|
|
Abstract
|
|
|
|
Secondary brain tumors after cranial irradiation have been reported in survivors of child-hood acute lymphoblastic leukemia (ALL). We report a case of secondary oligoden-droglioma, occurring in a 19-year-old male, 12 years after the diagnosis of ALL. He was treated with vincristine, asparaginase, doxorubicin, methotrexate, prednisone, 6-mercap-topurine and cytarabine followed by prophylactic cranial irradiation at the age of 7 years. After treatment of ALL was completed at the age of 10 years, he showed symptoms of seizure, headache and decreased visual acuity at the age of 19 years. Magnetic reso-nance imaging (MRI) of the brain showed a mass lesion which was revealed as low-grade oligodendroglioma by stereotactic biopsy. He was treated with cranial radio-therapy, followed by 4 cycles of chemotherapy composed of PCV (procarbazine, meth-yl-1-(2-chloroethyl)-1-nitrosourea (CCNU), and vincristine) for oligodendroglioma, and sodium valproate for seizure control. The patient showed stable disease and no re-currence of seizure 8 months after treatment.
|
|
|
KEYWORD
|
|
|
Oligodendroglioma, Childhood, Acute lymphoblastic leukemia, Cranial irra-diation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|